About DNA Testing & Who Needs It

What is DNA test & do I need it?

Why do I need a DNA test?

Your DNA can tell you a lot about you like if you’re more sensitive to fat than others, whether you should incorporate more Vitamin C into your diet if you are more sensitive to caffeine than your friends, what type of exercises are more suitable for you, and many more.

Your DNA can even tell you if you’re more likely to develop certain types of disease such as Type 2 diabetes, hypertension, gout and more. Together, your DNA test will uncover a wide variety of important health insights.

We empower you to truly understand these unique puzzles about yourself and recommend actions you can take to begin your personalised nutrition and health journey.

Who is the test suitable for?

The test is suitable for anyone who is curious to understand how their DNA affects their nutrition, diet and workout plans.

Whether you want to lose weight, eat healthier, exercise smarter, or just be healthier, your DNA profile will provide you with valuable information on the most suitable diet and lifestyle for you.

How will I be tested?

We need your saliva sample to discover the missing puzzles in your DNA. DNA will be obtained from some white blood and inner cheeks skin cells found in the saliva sample.

What is the science behind this?

Your DNA genotyping results are based on thousands of published research articles, proving relevant effects on nutrition and fitness response, with easily actioned lifestyle changes. Genotyping looks at specific points in your DNA and identifies variations. These variations make you unique. In selecting these specific points, we target on variations that are known to be associated with important nutrition, traits and health diseases. Genotyping is a good way to understand how your DNA can impact your daily life.

How accurate is my report?

The genotyping process has a 99.9% accuracy validated. We process all test samples in our own laboratory.

All DNA categories tested are supported by a rigorous volume of research conducted by leading scientists and research institutes around the world.

About hereditary conditions

What are hereditary cancers?

Hereditary cancers refer to cancers that are more likely to occur due to inherited genetic mutation that is passed down from a parent to a child. Inheriting a gene mutation does not necessarily mean that you will develop cancer, but it increases the likelihood (compared to someone who has not inherited a mutated gene).

A DNA test can help you identify cancer-causing mutations in your genes. For example, there is an increased genetic risk of having breast cancer when an individual has a particular mutation in the BRCA1 gene. Even if this individual is a male, this mutation can still cause cancer in male breast. [However, note that > 80% men are not aware that men can get breast cancer too]. Additionally, as this is an inherited genetic condition, he may potentially pass it down to his daughter who then would have an increased genetic risk of breast cancer. Knowing your genetic risk for cancer empowers not just yourself but also your family to take preventive measures such as early screening for cancers with increased genetic risk. Your loved ones can benefit from knowing your DNA results. If there is an increased risk in one family member, there is a heightened chance that other family members may also have an increased risk.

At myPreciseDNA, we believe in the empowerment of individuals to take control of their health through the knowledge of their genetic blueprint. Using next-generation whole-exome sequencing technology, we analyse DNA samples to identify genetic risk for 36 cancers including breast, ovarian, colorectal, lung, liver, pancreas and more. Know your risk and take advantage of early screening and detection. The benefits are obvious. For many cancers, early detection can increase survival rates to more than 90%. 

What is carrier screening?

Carrier screening is a type of genetic test can help you find out if you carry a mutation for certain inherited genetic conditions that could be passed on to your child. Many of us are carriers of several genetic conditions, usually without any symptoms and without affecting our health. However, when two people are carriers for the same genetic condition and have children together, there is a one in four chance for the child inherting two mutated genes from both parents can have the genetic condition. Generally, the conditions detected by carrier screen are quite serious causing death or serious disability in early childhood. Hence, carrier screen helps to decrease this risk.

Examples of genetic conditions range from Deafness to more debilitating conditions such as Sickle Cell Disease (1) which can significantly affect a child’s quality of life and reduce life expectancy.

(1) Sickle Cell Disease is an inherited blood disorder which affects a major component of red blood cells, hemoglobin, and results in red blood cells having a stiff crescent shape resembling a sickle. Adequate levels of red blood cells and hemoglobin are needed for efficiently delivering oxygen to all the cells in your body. As the sickled blood cells die prematurely, poor delivery of oxygen to our body causes a person to feel weak and tired. These sickled cells can also get stuck in small blood vessels, blocking blood flow and causing serious medical complications such as tissue deterioration.

Do I need carrier screening if my family does not have history of inherited conditions?

Many of us are carriers of inherited conditions and simply do not know it. Over 80% of children with inherited conditions are born to parents who aren’t aware they carry the variant. Many inherited conditions, such as Sickle Cell Disease (1) and Cystic Fibrosis (2), may have no family history on either parent’s side. This happens because having just one copy of a mutation does not usually cause any symptoms, so many people are “carriers” for inherited conditions without ever knowing it. Almost all of these conditions have what is called “autosomal recessive inheritance” where an affected child has to inherit a copy of a gene with the disease-causing mutation from each parent. Hence, if two people who are carriers for the same condition have children together, each child has a 1 in 4 chance of being born with the condition.

Individually, inherited conditions may be rare. However, collectively, there is at least a 1 in 3 chance that you are a carrier of at least one of the tested conditions. This is much higher than the incidence of Down syndrome. Knowing your risk profile before or early in a pregnancy allows you to consider your options with time to make choice, together with your healthcare provider.

(1) Sickle Cell Disease is an inherited blood disorder which affects a major component of red blood cells, hemoglobin, and results in red blood cells having a stiff crescent shape resembling a sickle. The sickled blood cells die prematurely, causing a person to feel weak and tired. These sickled cells can also get stuck in small blood vessels, blocking blood flow and causing serious medical complications such as tissue deterioration.

(2) Cystic Fibrosis is a severe condition that can affect different parts of the body such as lungs, bowel, pancreas etc. This disease is caused by a gene called CFTR. When CFTR does not function well due to genetic mutation, mucus can become thick and sticky clogging passages such as breathing airways and bowel. Healthy mucus is needed for clearing germs and with thick mucus, germs can get trapped. This can cause frequent lung infections and death in childhood or early adulthood.

Testing of DNA

Where is my DNA tested?

Your DNA is tested at our laboratory, Synapse Sdn Bhd. The laboratory is equipped with the latest Next Generation Sequencing and Genotyping technologies and is supervised by a panel of expert geneticists, pathologists, informaticians and counsellors.

Your report is simplified so that you can understand with ease. We also provide counselling services with an expert genetic counsellor.

Please refer to the Store.

Snapshot:

A sample of myPreciseDNA Report

This is how your report will look like. Unveiling 128 traits, let this information guide you to a healthier path.

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